P176 After weight loss: two-year outcomes following a weight management programme in difficult-to-treat asthma and obesity

• DOI: 10.1136/thorax-2024-btsabstracts.337
• Publication Date: 2024-11-04T09:40:54Z
• Authors: V Sharma; HC Ricketts; L McCombie; N Brosnahan; L Crawford; L Slaughter; A Goodfellow; F Steffensen; R Chaudhuri; MEJ Lean; DC Cowan
• Keywords: Weight management; Management of obesity

<h3>Introduction</h3> We delivered a one-year weight management programme (Counterweight Plus, CWP) in participants with difficult-to-treat asthma and obesity single-centre randomised controlled trial resulting median loss of 14kg improvements Asthma Quality Life Questionnaire (AQLQ) exacerbation frequency at one-year. CWP was dietitian-supported total diet replacement lasting one year total. Following this, were invited back after intervention completion the two-year mark for further assessments. Here we report outcomes two years. <h3>Methods</h3> (1:1 CWP: Usual Care, UC) adults body mass index (BMI) ≥30kg/m². dietitian support: 12-week phase (850kcal/day low-energy formula); stepwise food reintroduction maintenance up to Study visits occurred baseline, four months, Outcomes measured include AQLQ (defined as courses high dose oral corticosteroid required achieve symptom control). <h3>Results</h3> Of 35 23 attended two-years: 9 14 UC. Median decreased from 103.0 (IQR 100.1 115.4kg) baseline 96.0 (91.7 97.6kg) years (Wilcoxon test p=0.008), no change UC (p=0.224). Mean (95% CI) score (minimal clinically important difference is 0.5) improved 3.9 (3.3, 4.5) 4.4 (3.9, 5.0) (p=0.049) (p=0.611). annualised reduced 4 (2 5) 2 (1 3) p=0.004) (0.623). <h3>Conclusion</h3> Our results suggest persistent improvement loss, stopping CWP, though between group differences observed. Observations are limited by small numbers there signs regain compared likely associated reduction asthma-related outcomes. Despite signals suggesting benefit CWP. A larger sample study needed confirm.