Oral administration of Lactobacillus salivarius inhibits the allergic airway response in mice

• DOI: 10.1139/w10-024
• Publication Date: 2010-06-16T16:52:09Z
• Authors: Chia-Yang Li; Hung-Chih Lin; Kai-Chung Hsueh; Shu-Fen Wu; Shih-Hua Fang
• Keywords: Lactobacillus salivarius; Splenocyte

Asthma is recognized throughout the world as a chronic airway inflammatory disease. In this study, we investigated effect of probiotics in response to antigen challenge an ovalbumin (OVA)-sensitized asthma model BALB/c mice. Lactobacillus salivarius PM-A0006 was orally administered mice before challenge. After challenge, serum OVA-specific antibody levels, responsiveness methacholine, influx cells lung, and cytokine levels bronchoalveolar lavage (BAL) fluid splenocytes were assessed. Oral treatment with live L. significantly attenuated eosinophils lumen reduced IgE eotaxin BAL antigen-challenged animals. Furthermore, also decreased allergen-induced hyperresponsiveness elevated IFN-γ. These results showed that oral could have therapeutic potential allergic