Anti-hepatitis C Virus Effect of Citrus Unshiu Peel and Its Active Ingredient Nobiletin

• DOI: 10.1142/s0192415x05002680
• Publication Date: 2005-03-31T12:25:00Z
• Authors: Megumi Suzuki; Kenroh Sasaki; Fumihiko Yoshizaki; Min Fujisawa; Katsuji Oguchi; Jong-Chol Cyong
• Keywords: Citrus unshiu; Nobiletin; Ingredient

We investigated the effects of water and ethyl acetate extracts Citrus unshiu peel (Aurantii Nobilis pericarpium) on hepatitis C virus (HCV) absorption in MOLT-4 cells (a human lymphoblastoid leukemia cell line). By reverse transcription polymerase chain reaction (RT-PCR), we showed that both layer extract fraction 7 decreased HCV cells. Furthermore, demonstrated 3',4',5,6,7,8-hexamethoxyflavone (nobiletin) is active ingredient markedly inhibited infection