High-throughput evaluation of synthetic metabolic pathways

• DOI: 10.1142/s233954781640001x
• Publication Date: 2015-12-17T04:12:20Z
• Authors: Justin R. Klesmith; Timothy A. Whitehead
• Keywords: Metabolic Engineering; Metabolic pathway; Identification

A central challenge in the field of metabolic engineering is efficient identification a pathway genotype that maximizes specific productivity over robust range process conditions. Here we review current methods for optimizing pathways living cells. New tools library generation, computational analysis sequence-flux space, and high-throughput screening selection techniques are discussed.