Association between Liver MRI Proton Density Fat Fraction and Liver Disease Risk

• DOI: 10.1148/radiol.231007
• Publication Date: 2023-10-24T13:47:49Z
• Authors: Tianyi Xia; Mulong Du; Huiqin Li; Yuancheng Wang; Junhao Zha; Tong Wu; Shenghong Ju
• Keywords: Mendelian Randomization; Liver disease; Chronic liver disease

Background A better understanding of the association between liver MRI proton density fat fraction (PDFF) and diseases might support clinical implementation PDFF. Purpose To quantify genetically predicted causal effect PDFF on disease risk. Materials Methods This population-based prospective observational study used summary-level data mainly from UK Biobank FinnGen. Mendelian randomization analysis was conducted using inverse variance–weighted method to explore risk with Bonferroni correction. The individual-level were downloaded August December 2020 Biobank. Logistic regression performed validate polygenic score Mediation analyses multivariable mendelian randomization. Results Summary-level obtained 32 858 participants 378 436 (mean age, 57 years ± 8 [SD]; 203 108 female participants), respectively. Genetically high associated increased risks malignant neoplasm (odds ratio [OR], 4.5; P < .001), alcoholic (OR, 1.9; fibrosis cirrhosis 3.0; .004), 3.6; = .002), 3.8; nonalcoholic steatohepatitis 7.7; fatty (NAFLD) 4.4; .001). Individual-level evidence supported these associations after grouping based (all .004). mediation indicated that high-density lipoprotein cholesterol, type 2 diabetes mellitus, waist-to-hip (mediation effects, 25.1%–46.3%) related occurrence liver, NAFLD at .05). Conclusion provided health. © RSNA, 2023 Supplemental material is available for this article. See also editorials by Reeder Starekova Monsell in issue. An earlier incorrect version appeared online. article corrected October 31, 2023.