Angiographic appearance of recurrent malignant melanoma before and after intra-arterial chemotherapy.

• DOI: 10.1148/radiology.142.2.7198811
• Publication Date: 2014-07-08T21:23:49Z
• Authors: C Charnsangavej; V P Chuang; S Wallace; C S Soo; T Bowers
• Keywords: Angiography; Antineoplastic Agents; Extremities; 3. Good health; Dacarbazine; 03 medical and health sciences; 0302 clinical medicine; Humans; Infusions, Intra-Arterial; Drug Therapy, Combination; Cisplatin; Neoplasm Recurrence, Local; Melanoma

Intra-arterial infusion of chemotherapeutic agents (CDDP alone or combined with DTIC) was used to treat recurrent melanoma in 22 patients. In 17 cases, sequential arteriograms were obtained before and after infusion to monitor the procedure. Pre-treatment angiograms usually demonstrated rounded nodules with a homogeneous, hypervascular stain. In 3 patients, additional deep-seated lesions which were not palpable clinically were detected by angiography. Arteriograms of those patients who responded to chemotherapy revealed partial or complete disappearance of tumor stain. A 46% response rate was observed. The authors feel that angiography is valuable in pre-treatment diagnosis and post-treatment evaluation of recurrent melanoma.