Electrochemical Detection of NG-Hydroxy-L-Arginine

• DOI: 10.1149/08513.1163ecst
• Publication Date: 2018-07-13T09:47:52Z
• Authors: Mariah Lynn Arral; Jeffrey Mark Halpern
• Keywords: Differential pulse voltammetry

NG-hydroxy-L-arginine (NOHA) is a stable intermediate product in the consumption of L-arginine urea cycle by nitric oxide synthase (NOS) to produce (NO) and L-citrulline. Research has shown that disrupted various diseases. As one few electrochemically active species cycle, NOHA shows promise as marker for detection Electrochemical an established, cost-effective method able successfully detect low levels analyte concentrations. NOHA, best our knowledge, not been detected previously. Using cyclic voltammetry with glassy carbon electrode, we have found oxidation peak at 355 mV sensitivity 5.4 nA/µM. We also investigated detecting differential pulse voltammetry, which similar peaks. While there significant work ahead understand kinetics detection, results here represent first steps making biosensor.