Regulatory effects of estrogen on acute lung inflammation in mice

• DOI: 10.1152/ajpcell.00467.2004
• Publication Date: 2005-03-11T01:07:39Z
• Authors: Cecilia L. Speyer; Nicholas J. Rancilio; Shannon D. McClin...; Jeffrey D. Crawford; Hongwei Gao; J. Vidya Sarma; Peter A. Ward
• Keywords: Inflammation; Lipopolysaccharides; Lung Diseases; Male; 0303 health sciences; Neutrophils; Ovariectomy; Estrogens; 3. Good health; Mice; 03 medical and health sciences; Animals; Female; Chemokines; Bronchoalveolar Lavage Fluid; Cell Adhesion Molecules; Lung

The role of estrogen in the regulation inflammatory response is not well defined. In this study, we investigated effects ovarian hormones on acute mouse lungs. Acute lung injury was induced by intratracheal instillation bacterial lipopolysaccharide (LPS) male, female, and ovariectomized (OVX) mice. End points were polymorphonuclear neutrophil (PMN) content bronchoalveolar lavage (BAL) fluids, myeloperoxidase activity whole lung, leak albumin into lung. After LPS, all end substantially increased male OVX mice compared with female intact ovaries. BAL fluids showed similar levels chemokines (macrophage protein MIP-2, KC, monocyte chemoattractant proteins MCP-1 MCP-3) TNF-alpha, but enhanced IL-1beta found Serum IL-6 ICAM-1 homogenates from mice, those ovaries, also after LPS. Albumin PMN LPS-injured lungs reduced to administration estradiol corresponded IL-1beta, IL-6, levels. These data suggest that suppresses responses through an effect vascular cell adhesion molecules proinflammatory mediators.