Postnatal surge of adipose-secreted leptin is a robust predictor of fat mass trajectory in mice

• DOI: 10.1152/ajpendo.00237.2024
• Publication Date: 2024-10-23T15:00:30Z
• Authors: Olga Horakova; Petra Janovska; Ilaria Irodenko; Jana Buresova; Inge van der Stelt; Sara Stanic; Eliska Haasova; Nivasini Shekhar; Tatyana Kobets; Jaap Keijer; Petr Zouhar; Martin Rossmeisl; Jan Kopecky; Kristina Bardova
• Keywords: 0301 basic medicine; 03 medical and health sciences; Life Science

The postnatal surge in circulating leptin levels in mice reflects particularly posttranscriptionally controlled release of this hormone from subcutaneous white adipose tissue. Leptinemia in 2-wk-old pups predicts both body weight and adiposity in adult mice fed a high-fat diet. The extent of these effects depends on genetically determined differences in propensity to obesity between C57BL/6 and A/J mice. The leptin effect on adiposity is compromised in the obesity-prone C57BL/6 mice.