Catabolic to anabolic transition during nutritional rehabilitation of female adolescents with anorexia nervosa
DOI:
10.1152/ajpendo.00523.2024
Publication Date:
2025-04-25T16:30:39Z
AUTHORS (10)
ABSTRACT
We provide a comprehensive temporal characterization of changes in biochemical markers of glucose homeostasis, GH-IGF-1 axis activity, and adipose tissue, bone, and protein metabolism during refeeding of adolescents with anorexia nervosa. Although IGF-I levels increased continuously, other markers showed a biphasic pattern: an early decrease in catabolic markers, followed by an increase in anabolic markers later during hospitalization. IGF-1, urea/creatinine ratio, and klotho emerged as potential clinical biomarkers of catabolic to anabolic transition in patients with severe malnutrition.
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