Catabolic to anabolic transition during nutritional rehabilitation of female adolescents with anorexia nervosa

• DOI: 10.1152/ajpendo.00523.2024
• Publication Date: 2025-04-25T16:30:39Z
• Authors: Yael Levy-Shraga; Idit Ron; Adi Enoch-Levy; Rina Hemi; Hannah Kanety; Ido Wolf; Daniel Stein; Amir Tirosh; Tami Rubinek; Dalit Modan-Moses
• Keywords: Anorexia nervosa; Catabolism

Anorexia nervosa (AN) is associated with profound changes in glucose homeostasis, activity of the GH-IGF-1 axis, and adipose tissue, bone, protein metabolism. We aimed to characterize transition from catabolic anabolic state during nutritional rehabilitation female adolescent inpatients AN. The study comprised 41 patients (aged 15.6±1.6 years). Blood samples were obtained at time admission, upon attainment target weight. A subgroup 18 also had blood early refeeding period. Changes BMI BMI-SDS hospitalization (5.1±2.0 months) positively correlated markers anabolism including IGF-1 (r=0.424, p=0.006), P1NP (r=0.375, p=0.016), klotho (r=0.468, p=0.002), alkaline phosphatase (ALP) (r=0.051, p=0.001), negatively change cortisol levels (r=-0.331, p=0.035). Furthermore, inter-correlated. increased consistently throughout period (p<0.001), however other variables showed a biphasic pattern. During period, there was decrease CTX-1 uric acid (p=0.056), FABP4 (p=0.04) (p=0.038) levels, while urea/creatinine ratio (UCR) (p=0.045) increased. later phase, an increase ALP (p=0.039), insulin (p=0.04), HOMA-IR (p=0.06) (p=0.02). In conclusion, characterized by catabolism, phase markers. suggest that IGF-1, UCR, may be used as reversal catabolism shift towards severe malnutrition.