Catabolic to anabolic transition during nutritional rehabilitation of female adolescents with anorexia nervosa

• DOI: 10.1152/ajpendo.00523.2024
• Publication Date: 2025-04-25T16:30:39Z
• Authors: Yael Levy-Shraga; Idit Ron; Adi Enoch-Levy; Rina Hemi; Hannah Kanety; Ido Wolf; Daniel Stein; Amir Tirosh; Tami Rubinek; Dalit Modan-Moses

We provide a comprehensive temporal characterization of changes in biochemical markers of glucose homeostasis, GH-IGF-1 axis activity, and adipose tissue, bone, and protein metabolism during refeeding of adolescents with anorexia nervosa. Although IGF-I levels increased continuously, other markers showed a biphasic pattern: an early decrease in catabolic markers, followed by an increase in anabolic markers later during hospitalization. IGF-1, urea/creatinine ratio, and klotho emerged as potential clinical biomarkers of catabolic to anabolic transition in patients with severe malnutrition.