Gastric emptying, mouth-to-cecum transit, and glycemic, insulin, incretin, and energy intake responses to a mixed-nutrient liquid in lean, overweight, and obese males

• DOI: 10.1152/ajpendo.00533.2012
• Publication Date: 2012-12-05T10:59:44Z
• Authors: Radhika V. Seimon; Ixchel M. Brennan; Antonietta Russo; Tanya J. Little; Karen L. Jones; Scott Standfield; Judith M. Wishart; Michael Horowitz; Christine Feinle-...
• Keywords: Incretin

Observations relating to the impact of obesity on gastric emptying (GE) and secretion gut hormones are inconsistent, probably because a lack studies in which GE, gastrointestinal hormone release, energy intake (EI) have been evaluated concurrently with previous patterns nutrient intake. GE is known be major determinant postprandial glycemia incretin health type 2 diabetes. The aims this study were determine effects mixed-nutrient drink oro-cecal transit, blood glucose, insulin concentrations EI, relationship between glycemic response lean, overweight, obese subjects. Twenty 20 males had measurements insulin, GLP-1, GIP for 5 h after ingestion (500 ml, 532 kcal); EI at subsequent buffet lunch was determined. Habitual also quantified. Glycemic insulinemic responses greater (both P < 0.05) when compared both lean no significant differences intragastric distribution, incretins, or (buffet habitual) groups. magnitude rise glucose relatively more rapid (r = -0.55, 0.05). In conclusion, absence habitual unaffected despite responses, glycemia.