Simultaneous treatment with IGF-I and GH additively increases anabolism in parenterally fed rats

• DOI: 10.1152/ajpendo.1995.269.2.e368
• Publication Date: 2017-12-22T04:55:50Z
• Authors: H. C. Lo; P. S. Hinton; C. A. Peterson; D. M. Ney
• Keywords: Somatomedin

We compared the effects of recombinant human insulin-like growth factor I [rhIGF-I, 800 micrograms/day, coinfused with total parenteral nutrition (TPN)], hormone (rhGH, subcutaneous injection twice daily), and simultaneous treatment rhIGF-I rhGH (800 + micrograms/day) in rats subjected to surgical stress maintained TPN. Weight gain induced by IGF-I plus GH was double that shown or alone. Although weight similar GH, selectively increased heart, kidney, thymus, spleen, small intestine mass, whereas gastrocnemius muscle mass. and/or carcass protein water while decreasing fat. Serum free levels were highest GH. rat reduced given reversed GH-induced increase serum insulin. In summary, show tissue-specific anabolic effects, additively increases anabolism during