Effect of caloric intake and macronutrient composition on intestinal cholesterol absorption and bile acids in patients with obesity

• DOI: 10.1152/ajpgi.00108.2022
• Publication Date: 2022-06-21T13:47:10Z
• Authors: Anas Mohamad Hashem; Lizeth Cifuentes; Gerardo Calderon; Maria Laura Ricar...; Daniel Gonzalez-I...; Alejandro Campos; Alison McRae; Shawna Franks; Maria Daniela Hur...; Duane Burton; Xuan-Mai Petterson; Ian R. Lanza; Michael Camilleri; Andres Acosta
• Keywords: Caloric theory; Caloric intake

Obesity is associated with alterations in cholesterol and bile acid (BA) metabolism. However, the interaction among dietary intake, absorption, BA metabolism patients obesity remains unclear. We conducted a 4-wk nutritional intervention nonrandomized clinical trial three different sequential diets for week following order: regular diet (RD); high calorie, high-fat (HCHF), washout period on RD; low-calorie, low-fat (LCLF). provided participants meal replacements during HCHF LCLF diets. A total of 16 completed study [