Effects of corticotropin-releasing hormone on gastric electrical activity and sensorimotor function in healthy volunteers: a double-blinded crossover study

• DOI: 10.1152/ajpgi.00298.2023
• Publication Date: 2024-02-20T09:01:23Z
• Authors: I-Hsuan Huang; Jolien Schol; Stefan Calder; Armen A. Gharibans; Karen Van den Houte; Annelies Verheyden; Bert Broeders; Florencia Carbone; Greg O'Grady; Jan Tack
• Keywords: Crossover study; Double blinded; Corticotropin-releasing hormone

In healthy volunteers, peripheral corticotropin-releasing hormone (CRH) infusion accelerates gastric-emptying rate and increases postprandial gastric response, accompanied by a rise in symptoms, but does not alter sensitivity or meal-induced accommodation. These findings underscore significant link between stress dyspeptic with CRH playing pivotal role mediating these effects.