Human pancreatic secretion and intestinal motility: effects of ileal nutrient perfusion

• DOI: 10.1152/ajpgi.1990.258.2.g196
• Publication Date: 2017-12-24T07:02:28Z
• Authors: P. Layer; S. Peschel; T. Schlesinger; H. Goebell
• Keywords: Intestinal motility

To study the effects of intraileal nutrients on human pancreatic secretion and gastrointestinal motility, nine healthy subjects were intubated with an oroileal multilumen tube for ileal perfusion, duodenal juice aspiration, intestinal motility recording. The duodenum was perfused continuously essential amino acids to induce submaximal stimulation enzyme fed pattern. Additional perfusion carbohydrate at quantities similar those observed under physiological late postprandial conditions or fat isocaloric loads significantly decreased outputs by greater than 80% (P less 0.001) compared saline. Ileal induced a motor activity front that migrated distally followed reduced motility. In summary, delivery small nutrient markedly endogenously stimulated in humans. This associated specific changes converted patterns characteristic interdigestive state. Our findings suggest distal intestine may participate regulation function