Dietary diosgenin attenuates subacute intestinal inflammation associated with indomethacin in rats
0301 basic medicine
0303 health sciences
Dose-Response Relationship, Drug
Body Weight
Indomethacin
Diosgenin
Enteritis
Diet
Rats
3. Good health
Bile Acids and Salts
Eating
03 medical and health sciences
Blood
Cholesterol
Acute Disease
Animals
Bile
Filtration
DOI:
10.1152/ajpgi.1997.273.2.g355
Publication Date:
2017-12-24T12:10:07Z
AUTHORS (15)
ABSTRACT
We investigated the effects of dietary diosgenin (Dio), a plant-derived sapogenin, on indomethacin (Indo)-induced intestinal inflammation and alterations in bile secretion in rats. In anesthetized rats, bile secretion, intestinal inflammation, and blood chemistry were assessed 3 days after two subcutaneous injections of Indo given 24 h apart. Dio (> 80 mg.kg-1.day-1) pretreatment significantly inhibited weight and food intake decreases and intestinal inflammation. This protective effect was confirmed by examination of gross and histological findings and intestinal myeloperoxidase activity. Dio significantly increased biliary cholesterol (Chol) output and prevented the decreases in bile flow, bile acid output, and biliary alpha-muricholic acid and the increases in biliary hyodeoxycholic acid, deoxycholic acid, and hydrophobicity index of bile. Significantly more biliary Chol and phospholipids were present in macromolecules separate from bile acids and Indo in Dio-treated rats. Dio significantly increased the elimination constant of Indo and reduced plasma Indo levels at 3 and 12 h but did not influence biliary secretion of Indo for 3.5 h after injection. Although Dio dose-dependently attenuated subacute intestinal inflammation and normalized bile secretion in this model, it may also compromise the anti-inflammatory action of indo.
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