Dietary diosgenin attenuates subacute intestinal inflammation associated with indomethacin in rats

• DOI: 10.1152/ajpgi.1997.273.2.g355
• Publication Date: 2017-12-24T12:10:07Z
• Authors: T. Yamada; M. Hoshino; T. Hayakawa; H. Ohhara; H. Yamada; T. Nakazawa; T. Inagaki; M. Iida; T. Ogasawara; A. Uchida; C. Hasegawa; G. Murasaki; M. Miyaji; A. Hirata; T. Takeuchi
• Keywords: Diosgenin

We investigated the effects of dietary diosgenin (Dio), a plant-derived sapogenin, on indomethacin (Indo)-induced intestinal inflammation and alterations in bile secretion rats. In anesthetized rats, secretion, inflammation, blood chemistry were assessed 3 days after two subcutaneous injections Indo given 24 h apart. Dio (> 80 mg.kg-1.day-1) pretreatment significantly inhibited weight food intake decreases inflammation. This protective effect was confirmed by examination gross histological findings myeloperoxidase activity. increased biliary cholesterol (Chol) output prevented flow, acid output, alpha-muricholic increases hyodeoxycholic acid, deoxycholic hydrophobicity index bile. Significantly more Chol phospholipids present macromolecules separate from acids Dio-treated elimination constant reduced plasma levels at 12 but did not influence for 3.5 injection. Although dose-dependently attenuated subacute normalized this model, it may also compromise anti-inflammatory action indo.