Luminal fructose modulates fructose transport and GLUT-5 expression in small intestine of weaning rats

• DOI: 10.1152/ajpgi.1998.274.2.g232
• Publication Date: 2017-12-24T09:17:56Z
• Authors: Rong Shu; Elmer S. David; Ronaldo P. Ferraris
• Keywords: Jejunum; Brush border

In neonatal rats, precocious introduction of dietary fructose significantly enhances brush-border transport rates and GLUT-5 mRNA levels during early weaning. this study, these were more than two times higher in the anastomosed intestine compared with those bypassed loop weaning pups that underwent Thiry-Vella surgery consumed high-fructose (HF) diets. fed fructose-free (NF) diets, uptake very low similar to loop. sham-operated littermates, between intestinal regions corresponded loops three greater HF NF diet. contrast, glucose SGLT-1 GLUT-2 independent diet regions. Changes expression did not follow a distinct diurnal rhythm. When after 12 h starvation empty lumen, increased feeding duration reached plateau 12–24 feeding; highest within 4 arrival chyme jejunum then decreased gradually returned baseline 24 later. littermates diet, each duration. Luminal, endocrine, signals regulate pups.