Abnormal neurovascular control during exercise is linked to heart failure severity

• DOI: 10.1152/ajpheart.2001.280.3.h1286
• Publication Date: 2017-12-22T08:54:39Z
• Authors: Carlos Eduardo Ne...; Maria Urbana P. B...; Taís Tinucci; Maria Janieire N....; Fabiana Roveda; Ana Maria W. Braga; Soraya F. Reis; Luciano Nastari; Antonio Carlos P....; Eduardo M. Krieger; Holly R. Middlekauff
• Keywords: Sympathetic nervous system; Microneurography

The purpose of this study was to determine if abnormalities sympathetic neural and vascular control are present in mild and/or severe heart failure (HF) the underlying afferent mechanisms. Patients with HF, age-matched controls were studied. Muscle nerve activity (MSNA) forearm resistance (FVR) nonexercising arm measured during moderate static handgrip. MSNA handgrip higher at baseline throughout exercise HF vs. (peak 67 +/- 3 54 bursts/min, P < 0.0001) (33 0.0001), but change not different between groups. FVR significantly three groups exercise. During isolation muscle metaboreceptors, blood pressure remained elevated normal HF. handgrip, increase exaggerated whom did increase. In summary, appears be attributable central command or mechanoreceptor control, metaboreceptor control.