Quantification of 3-D regional myocardial deformation: shape-based analysis of magnetic resonance images

• DOI: 10.1152/ajpheart.2001.281.2.h698
• Publication Date: 2017-12-22T14:45:32Z
• Authors: Albert J. Sinusas; Xenophon Papademe...; R. Todd Constable; Donald P. Dione; Martin D. Slade; Pengcheng Shi; James S. Duncan
• Keywords: Endocardium; Cardiac cycle; Radial stress; Cardiac magnetic resonance; Apex (geometry); Cardiac Imaging; Short axis

A comprehensive three-dimensional (3-D) shape-based approach for quantification of regional myocardial deformations was evaluated in a canine model (n = 8 dogs) with the use cine magnetic resonance imaging. The shape endocardial and epicardial surfaces used to track 3-D trajectories dense field points over cardiac cycle. surface displacements are integrated continuum biomechanics incorporating myofiber architecture estimate both cardiac- fiber-specific strains shears 24 left ventricular regions. Whereas radial circumferential end-systolic were fairly uniform, there significant apex-to-base gradient longitudinal strain radial-longitudinal shear. We also observed transmural epicardial-to-endocardial gradients strains. increase accompanied by increases shear radial-fiber endocardium, supporting previous theories deformation that predict considerable sliding between fibers.