Prolactin regulates liver growth during postnatal development in mice

• DOI: 10.1152/ajpregu.00003.2018
• Publication Date: 2018-02-21T23:36:03Z
• Authors: Bibiana Moreno-Ca...; Marco Bravo-Manrí...; Arelí Baez; Maria G. Ledesma-...; Xarubet Ruiz-Herrera; Pamela Reyes-Ortega; Ericka A. de los ...; Yazmín Macotela; Gonzalo Martínez ...; Carmen Clapp
• Keywords: Male; Mice, Knockout; 0301 basic medicine; Receptors, Prolactin; Neovascularization, Physiologic; Suppressor of Cytokine Signaling Proteins; Growth; Prolactin; Mice, Inbred C57BL; Mice; 03 medical and health sciences; Liver; Pregnancy; Suppressor of Cytokine Signaling 3 Protein; Animals; Female; Insulin-Like Growth Factor I; Cell Proliferation

The liver grows during the early postnatal period first at slower and then faster rates than body to achieve adult liver-to-body weight ratio (LBW), a constant reflecting health. hormone prolactin (PRL) stimulates growth regeneration, its levels are high in circulation of newborn infants, but whether PRL plays role neonatal is unknown. Here, we show that produces upregulates receptor mice 2 wk after birth, when lags behind growth. At week 4, production by ceases coinciding with elevation circulating catches up null ( Prlr−/−) significant decrease LBW 1, 6, 10 weeks reduced expression proliferation [cyclin D1 Ccnd1)] angiogenesis [platelet/endothelial cell adhesion molecule 1 Pecam1)] markers relative Prlr+/+ mice. However, increases Prlr−/− concurring enhanced Igf-1 upregulation downregulation suppressor cytokine signaling Socs2) Socs3, respectively. These findings indicate acts locally systemically restrict stimulate inhibits attenuating hormone-induced via Socs2 Socs3-related mechanisms.