Oxidized fish oil in rat pregnancy causes high newborn mortality and increases maternal insulin resistance

• DOI: 10.1152/ajpregu.00005.2016
• Publication Date: 2016-07-07T02:09:03Z
• Authors: Benjamin B. Albert; Mark H. Vickers; Clint Gray; Clare M. Reynolds; Stephanie A. Segovia; José G. B. Derraik; Paul A. Lewandowski; Manohar L. Garg; David Cameron-Smith; Paul L. Hofman; Wayne S. Cutfield
• Keywords: 0301 basic medicine; lipid peroxides; lipids; Rats, Sprague-Dawley; 03 medical and health sciences; Fish Oils; Pregnancy; Infant Mortality; pups; Animals; Humans; 2. Zero hunger; Infant; dams; n-3 polyunsaturated fatty acids; Rats; 3. Good health; Pregnancy Complications; Animals, Newborn; Hyperglycemia; Dietary Supplements; Female; omega-3; Insulin Resistance; Oxidation-Reduction

Fish oil is commonly taken by pregnant women, and supplements sold at retail are often oxidized. Using a rat model, we aimed to assess the effects of supplementation with oxidized fish during pregnancy in mothers offspring, focusing on newborn viability maternal insulin sensitivity. Female rats were allocated control or high-fat diet then mated. These subsequently randomized receive daily gavage treatment 1 ml unoxidized oil, highly (water) throughout pregnancy. At birth, was stopped, but same diets fed ad libitum lactation. Supplementation had marked adverse effect survival day 2, leading much greater odds mortality than (odds ratio 8.26) 13.70) groups. In addition, intake led increased resistance time weaning (3 wks after exposure) compared dams (HOMA-IR 2.64 vs. 1.42; P = 0.044). data show that consumption harmful pregnancy, deleterious both offspring.