Effects of intraduodenal fatty acids on appetite, antropyloroduodenal motility, and plasma CCK and GLP-1 in humans vary with their chain length

• DOI: 10.1152/ajpregu.00039.2004
• Publication Date: 2004-06-01T00:34:00Z
• Authors: Kate L. Feltrin; Tanya J. Little; James H. Meyer; Michael Horowitz; Andre J. P. M. Smout; Judith Wishart; Amelia N. Pilichi...; Thomas Rades; Ian M. Chapman; Christine Feinle-...
• Keywords: Adult; Male; Duodenum; Manometry; Appetite; Pilot Projects; 03 medical and health sciences; Double-Blind Method; Glucagon-Like Peptide 1; Humans; Infusions, Parenteral; decanoic acid; 0303 health sciences; Fatty Acids; lauric acid; Lauric Acids; Middle Aged; Glucagon; Hormones; Peptide Fragments; 3. Good health; gastrointestinal peptides; gastrointestinal contractile activity; energy intake; Cholecystokinin; Energy Intake; Gastrointestinal Motility; Decanoic Acids

The gastrointestinal effects of intraluminal fats may be critically dependent on the chain length fatty acids released during lipolysis. We postulated that intraduodenal administration lauric acid (12 carbon atoms; C12) would suppress appetite, modulate antropyloroduodenal pressure waves (PWs), and stimulate release cholecystokinin (CCK) glucagon-like peptide-1 (GLP-1) more than an identical dose decanoic (10 C10). Eight healthy males (19-47 yr old) were studied three occasions in a double-blind, randomized fashion. Appetite perceptions, PWs, plasma CCK GLP-1 concentrations measured 90-min infusion 1) C12, 2) C10, or 3) control (rate: 2 ml/min, 0.375 kcal/min for C12/C10). Energy intake at buffet meal, immediately after completion infusion, was also quantified. but not suppressed appetite perceptions (P < 0.001) energy (control: 4,604 +/- 464 kJ, C10: 4,109 588 C12: 1,747 632 kJ; P 0.001, C12 vs. control/C10). induced nausea 0.001). stimulated basal pyloric pressures isolated PWs antral duodenal compared with 0.05 all). C10 transiently = had no effect markedly 0.004). increased 0.001), substantially greater 0.001); 0.05), whereas did not. In conclusion, there are major differences administered kcal/min, intake, gut hormone humans.