Inhibition of CYP450 pathways reduces functional sympatholysis in healthy young adults

• DOI: 10.1152/ajpregu.00173.2024
• Publication Date: 2025-04-21T11:20:13Z
• Authors: Alexander A. Buelow; Jacob E. Matney; Sarah M. Skillett; John D. Ashley; Jiwon Song; Chris Mixon; Amir Akbari Fakhr...; Matthew Stanford; Debra A. Bemben; Daniel J. Larson; J. Mikhail Kellawan

Evidence suggests that functional sympatholysis is an endothelial-dependent, nitric oxide and prostaglandin-independent process. We found that cytochrome P450-2C9 (CYP450-2C9) inhibition attenuated sympatholytic responses during dynamic handgrip exercise with superimposed lower body negative pressure. These data indicate that CYP450 pathways contribute to functional sympatholysis in young healthy humans.