Inhibition of CYP450 pathways reduces functional sympatholysis in healthy young adults

DOI: 10.1152/ajpregu.00173.2024 Publication Date: 2025-04-21T11:20:13Z
ABSTRACT
Evidence suggests that functional sympatholysis is an endothelial-dependent, nitric oxide and prostaglandin-independent process. We found that cytochrome P450-2C9 (CYP450-2C9) inhibition attenuated sympatholytic responses during dynamic handgrip exercise with superimposed lower body negative pressure. These data indicate that CYP450 pathways contribute to functional sympatholysis in young healthy humans.
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