Exertional heat stroke causes long-term skeletal muscle epigenetic reprogramming, altered gene expression, and impaired satellite cell function in mice

• DOI: 10.1152/ajpregu.00226.2023
• Publication Date: 2023-12-04T09:30:33Z
• Authors: Kevin O. Murray; Jason O. Brant; Ray A. Spradlin; Trace Thome; Orlando Laitano; Terence E. Ryan; Alberto Riva; Michael P. Kladde; Thomas L. Clanton

Exertional heat stroke (EHS) in mice induces long-term molecular and functional changes in limb muscle that could reflect a loss of “resilience” to further stress. The phenotype was characterized by altered caffeine sensitivity and suppressed satellite cell proliferative potential. This was accompanied by changes in gene expression and DNA methylation consistent with ongoing muscle remodeling and stress adaptation. We propose that EHS may induce a prolonged vulnerability of skeletal muscle to further stress or injury.