Endurance training enhances BDNF release from the human brain

• DOI: 10.1152/ajpregu.00525.2009
• Publication Date: 2009-11-18T22:01:10Z
• Authors: Thomas Seifert; Patrice Brassard; Mads Wissenberg; Peter Rasmussen; Pernille Nordby; Bente Stallknecht; Helle Adser; Anne H. Jakobsen; Henriette Pilegaard; Henning B. Nielsen; Niels H. Secher
• Keywords: Endurance Training

The circulating level of brain-derived neurotrophic factor (BDNF) is reduced in patients with major depression and type-2 diabetes. Because acute exercise increases BDNF production the hippocampus cerebral cortex, we hypothesized that endurance training would enhance release from human brain as detected arterial internal jugular venous blood samples. In a randomized controlled study, 12 healthy sedentary males carried out 3 mo (n = 7) or served controls 5). Before after intervention, samples were obtained at rest during exercise. At baseline, group (58 + - 106 ng x 100 g(-1) min(-1), means SD) control (12 17 min(-1)) had similar rest. Three months enhanced resting to 206 108 min(-1) (P < 0.05), no significant change subjects, but there was training-induced increase Additionally, eight mice completed 5-wk treadmill running protocol increased mRNA expression (4.5 1.6 vs. 1.4 1.1 mRNA/ssDNA; P not cortex (4.0 4.6 mRNA/ssDNA) compared untrained mice. following suggest promotes health.