Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production

• DOI: 10.1152/ajpregu.00767.2006
• Publication Date: 2007-06-22T01:04:57Z
• Authors: Florian L. Muller; Wook Song; Youngmok C. Jang; Yuhong Liu; Marian Sabia; Arlan Richardson; Holly Van Remmen
• Keywords: Muscle Atrophy; Mitochondrial ROS

Reactive oxygen species (ROS), especially mitochondrial ROS, are postulated to play a significant role in muscle atrophy. We report dramatic increase ROS generation three conditions associated with atrophy: aging, mice lacking CuZn-SOD (Sod1(-/-)), and the neurodegenerative disease, amyotrophic lateral sclerosis (ALS). mitochondria is nearly threefold higher 28- 32-mo-old than 10-mo-old 30% loss gastrocnemius mass. In Sod1(-/-) mice, production increased >100% 20-mo compared 5-mo-old along >50% ALS G93A mutant show 75% of mass during disease progression up 12-fold generation. second model, H46RH48Q approximately fourfold control less (30%) Thus strongly correlated extent atrophy these models. Because each models studied some degree innervation, we were interested determining whether denervation plays isolated from hindlimb following surgical sciatic nerve transection. Seven days post-denervation, 30-fold. conclude that enhanced may be common factor mechanism underlying denervation-induced