Circadian rhythm disorganization produces profound cardiovascular and renal disease in hamsters

• DOI: 10.1152/ajpregu.00829.2007
• Publication Date: 2008-02-14T01:45:43Z
• Authors: Tami A. Martino; Gavin Y. Oudit; Andrew M. Herzenberg; Nazneen Tata; Margaret M. Koletar; Golam M. Kabir; Denise D. Belsham; Peter H. Backx; Martin R. Ralph; Michael J. Sole
• Keywords: Proteomics; 0303 health sciences; Myocardium; Kidney Glomerulus; Blood Pressure; Motor Activity; Kidney; Kidney Function Tests; Immunohistochemistry; Mass Spectrometry; Body Temperature; Circadian Rhythm; 3. Good health; Microscopy, Electron; 03 medical and health sciences; Cardiovascular Diseases; Echocardiography; Heart Rate; Cricetinae; In Situ Nick-End Labeling; Animals; Electrophoresis, Polyacrylamide Gel; Kidney Diseases

Sleep deprivation, shift work, and jet lag all disrupt normal biological rhythms have major impacts on health; however, circadian disorganization has never been shown as a causal risk factor in organ disease. We now demonstrate devastating effects of rhythm cardiovascular renal integrity that interventions based principles prevent disease pathology caused by short-period mutation (tau) the system hamsters. The point regulatory gene, casein kinase-1epsilon, produces early onset entrainment with fragmented patterns behavior +/tau heterozygotes. Animals die at younger age cardiomyopathy, extensive fibrosis, severely impaired contractility; they also severe proteinuria, tubular dilation, cellular apoptosis. On light cycles appropriate for their genotype (22 h), cyclic behavioral are normalized, cardiorenal phenotype is reversed, hearts kidneys show structure function. Moreover, hypertrophy does not develop animals whose suprachiasmatic nucleus was ablated young adults. Circadian organization therefore critical health longevity, whereas chronic global asynchrony implicated etiology cardiac