Carbonic acid buffer changes during complete brain ischemia

• DOI: 10.1152/ajpregu.1986.250.3.r348
• Publication Date: 2017-12-24T17:26:13Z
• Authors: R. P. Kraig; W. A. Pulsinelli; F. Plum
• Keywords: pCO2; Mole; Carbonic acid

Simultaneous measurements of tissue PCO2 (PtCO2), interstitial H+ concentration ([H+]o), and lactate content were used to examine changes in HCO3- ([HCO3-]o) during complete ischemia. In normoglycemic rats (blood glucose 6-8 mM; neocortical ischemic-induced 8-12 mmol/kg) [H+]o increased from 7.22 +/- 0.02 6.79 pH (n = 3). By contrast, hyperglycemic 18-75 19-31 rose by a significantly larger amount 6.19 7). Given that is the predominant buffer, peak PtCO2 show why bimodally distributed compared with content. Between 8 12 mmol/kg lactate, when 99 186 Torr but was constant at pH, calculated [HCO3-]o 11.9 21.9 mM. Then after transitional changes, remained 389 9 7) despite fact ranged 19 31 respectively; must have 12.3 0.7 mM Since ischemic brain continued produce another more lactic acid above without further or [H+]o, been heterogeneously compartmented. The production occurred compartment occupied 36% space. This likely represent glial cells.