Role of prostaglandins on the renal effects of angiotensin and interstitial pressure during volume expansion

• DOI: 10.1152/ajpregu.1993.265.6.r1469
• Publication Date: 2017-12-25T01:49:26Z
• Authors: J. M. Pinilla; A. Alberola; J. D. Gonzalez; T. Quesada; F. J. Salazar
• Keywords: Captopril; Renal sodium reabsorption

This study was undertaken to determine, in anesthetized dogs, the role of renal prostaglandins (PG) mediating natriuretic response increased interstitial hydrostatic pressure (RIHP) during extracellular volume expansion (ECVE) with isotonic saline. It also determined if intrarenal angiotensin II (ANG II) effects ECVE are potentiated by inhibition PG synthesis. induced similar elevations RIHP, natriuresis, and fractional lithium excretion dogs treated (n = 7) not a synthesis inhibitor 5). In other experimental groups, maintenance ANG levels 6) infusing captopril into right artery were compared those simultaneous infusion captopril, II, 6). ECVE, blood flow glomerular filtration rate both kidneys when maintained constant significantly higher left kidney inhibited kidney. However, kidney, ECVE-induced increments natriuresis RIHP reduced same magnitude (36 53%, respectively) without (40 54%, inhibition. Our results indicate that PGs do play an important RIHP-induced decrements proximal sodium reabsorption. (ABSTRACT TRUNCATED AT 250 WORDS)