Activation of α2-receptors in the rostral ventrolateral medulla evokes natriuresis by a renal nerve mechanism

• DOI: 10.1152/ajpregu.2001.281.1.r98
• Publication Date: 2017-12-21T12:50:35Z
• Authors: Rubia Grecco Menegaz; Daniel R. Kapusta; Helder Mauad; Antonio de Melo C...
• Keywords: Rostral ventrolateral medulla; Renal medulla

The contribution of α 2 -receptor mechanisms in the rostral ventrolateral medulla (RVLM) mediating enhanced renal excretory responses evoked by intravenous infusion agonist xylazine was examined ketamine-anesthetized rats. In rats, bilateral microinjection antagonist yohimbine into RVLM significantly reduced levels urine flow rate (V) and urinary sodium excretion (UNaV) produced xylazine. contrast, chronically bilaterally renal-denervated rats xylazine-evoked diuretic, but not natriuretic, response. separate a near complete inhibition sympathetic nerve activity (RSNA). subsequent reversed this neural response concurrently decreased V UNaV. Together, these results indicate that during infusion, activates to selectively promote nerve-dependent pathway. activation affects handling water pathway independent nerves. This latter may involve an interaction with other brain regions involved antidiuretic hormone release (e.g., paraventricular nucleus hypothalamus).