Choline supplementation attenuates experimental sepsis-associated acute kidney injury

• DOI: 10.1152/ajprenal.00033.2022
• Publication Date: 2022-07-14T15:32:09Z
• Authors: Denise C. Hasson; Miki Watanabe-Cha...; Lindsey Romick-Ro...; Adeleine Koterba; Dashiell S. Miner; Patrick Lahni; Qing Ma; Stuart L. Goldstein; Prasad Devarajan; Stephen W. Standage
• Keywords: 0303 health sciences; Critical Illness; Acute Kidney Injury; Kidney; Choline; 3. Good health; Mice; 03 medical and health sciences; Sepsis; Dietary Supplements; Animals; Humans; Child

Altered choline metabolism plays a role in both human and murine sepsis-associated acute kidney injury (SA-AKI), and choline administration in experimental SA-AKI improved renal function. These findings indicate that 1) mouse models can help interrogate clinically relevant mechanisms and 2) choline supplementation may ameliorate human SA-AKI. Future research will investigate clinically the impact of choline supplementation on human renal function in sepsis and, using model systems, how choline mediates its effects.