Blood volume and protein responses to skin heating and cooling in resting subjects

• DOI: 10.1152/jappl.1983.54.2.515
• Publication Date: 2017-12-25T00:14:22Z
• Authors: M. H. Harrison; R. J. Edwards; L. A. Cochrane; M. J. Graveney
• Keywords: Adult; Male; Blood Volume; Hot Temperature; Rest; Osmolar Concentration; Sodium; Sweating; Blood Proteins; Hand; Cold Temperature; 03 medical and health sciences; 0302 clinical medicine; Regional Blood Flow; Skin Physiological Phenomena; Potassium; Humans; Skin Temperature

The effects of alterations in skin temperature on intravascular volume and protein content have been investigated in resting subjects. With a normal core temperature (Tac) both skin cooling and skin heating caused hemoconcentration, and heating was associated with an increased rate of protein loss from the intravascular space. Raising of the skin temperature after cooling, with Tac depressed, and cooling of the skin after heating, with Tac raised, were associated with an immediate reversal of the hemoconcentration, and gain of protein by the intravascular space. It is concluded that intravascular volume responses to thermal stress are dependent on the skin and core temperatures obtaining immediately prior to imposition of the stress and that, in particular, a low skin temperature predisposes toward hemodilution on subsequent exposure to heat; sweating per se does not necessarily result in hemoconcentration. The association of hemodilution with augmentation of intravascular protein, and the rapidity with which extravascular protein can apparently gain entry to the intravascular space, is taken as indicating a possible direct return of protein through capillary walls.