Comparison of two synthetic progesterones on ventilation in normal males: CMA vs. MPA

• DOI: 10.1152/jappl.1987.63.4.1610
• Publication Date: 2017-12-21T19:38:24Z
• Authors: T. Morikawa; Y. Tanaka; R. Maruyama; Y. Nishibayashi; Y. Honda
• Keywords: Hypocapnia; pCO2; Crossover study

We administered chlormadinone acetate (CMA), medroxyprogesterone (MPA), and placebo to 16 normal male subjects using a randomized double-blind crossover study. After CMA administration, minute alveolar ventilation increased by +1.04 +/- 0.22 (SE) 1/min (P less than 0.05) accompanied decrements of arterial PCO2 (-4.0 1.0 Torr) 0.01) [HCO3-] (-2.1 0.05 mM/l) 0.01). On the other hand, in MPA runs corresponding changes above parameters were +0.71 0.21 l/min 0.05), -2.9 0.6 Torr 0.01), -1.3 0.3 mM/l respectively. The slopes hypoxic ventilatory occlusion pressure response lines remained unchanged hypocapnia after or ingestion, but they when entidal was adjusted predrug level. hypercapnic merely shifted left without changing their with these agents. No significant differences all found between runs. concluded that males effect on similar MPA, despite fact luteinizing activity reported be approximately 10 times higher latter.