Time course evaluation of protein synthesis and glucose uptake after acute resistance exercise in rats

• DOI: 10.1152/jappl.2000.88.3.1142
• Publication Date: 2017-12-22T16:13:06Z
• Authors: Jazmir M. Hernandez; Mark J. Fedele; Peter A. Farrell
• Keywords: Basal (medicine); Exercise physiology

The temporal pattern for changes in rates of protein synthesis and glucose uptake after resistance exercise, especially relative to each other, is not known. Male Sprague-Dawley rats performed acute exercise ( n = 7) or remained sedentary 7 per group), the following were assessed vivo 1, 3, 6, 12 24 h later: synthesis, uptake, phosphatidylinositol 3-kinase (PI3-kinase) activity, p70 S6k activity. Rates mixed gastrocnemius muscle did increase until (e.g., at h, 138 ± 4 vs. exercised 178 6 nmol phenylalanine incorporated ⋅ g − 1 , mean SE, P < 0.05), whereas significantly elevated (sedentary 0.18 0.020 0.38 0.024 μmol 6-phosphate kg min 0.05). At still elevated, had returned basal levels. Arterial insulin concentrations different between groups any time. Non-insulin-stimulated activities PI3-kinase higher 12, and, generally, these occurred when (12 h) (6 but by exercise. These data suggest that regulators may respond same contraction-generated signals with kinetics they intra- extracellular are generated