Perioperative assessment of muscle inflammation susceptibility in patients with end-stage osteoarthritis

• DOI: 10.1152/japplphysiol.00428.2021
• Publication Date: 2022-03-03T16:43:20Z
• Authors: Devin J. Drummer; Jeremy S. McAdam; Regina Seay; Inmaculada Aban; Kaleen M. Lavin; Derek Wiggins; Gabriel Touliatos; Sufen Yang; Christian Kelley; S. Craig Tuggle; Brandon Peoples; Herrick Siegel; Elie Ghanem; Jasvinder A. Singh; Scott Schutzler; C. Lowry Barnes; Arny A. Ferrando; S. Louis Bridges; Marcas M. Bamman
• Keywords: Inflammation; Male; 0301 basic medicine; Myositis; Muscles; Middle Aged; Osteoarthritis, Knee; 16. Peace & justice; Fibrosis; 3. Good health; 03 medical and health sciences; Osteoarthritis; Quality of Life; Humans; Female; Aged

This study assessed the skeletal muscle molecular characteristics associated with end-stage osteoarthritis and refined an important phenotype, in some patients, termed muscle inflammation susceptibility (MuIS+) that may be an important consideration following surgery. Furthermore, we provide evidence of differential inflammatory and catabolic gene expression between the contralateral and surgical limbs along with differences between the skeletal muscle surrounding the diseased hip versus knee joints.