Pulmonary ventilation visualized using hyperpolarized helium-3 and xenon-129 magnetic resonance imaging: differences in COPD and relationship to emphysema

• DOI: 10.1152/japplphysiol.01206.2012
• Publication Date: 2012-12-14T03:33:56Z
• Authors: Miranda Kirby; Sarah Svenningsen; Nikhil Kanhere; Amir Owrangi; Andrew Wheatley; Harvey O. Coxson; Giles E. Santyr; Nigel A. M. Paterson; David G. McCormack; Grace Parraga
• Keywords: Male; Chronic Obstructive; hyperpolarized xenon-129 magnetic resonance imaging; 610; Contrast Media; Signal-To-Noise Ratio; Helium; Severity of Illness Index; chronic obstructive pulmonary disease; Pulmonary Disease; Pulmonary Disease, Chronic Obstructive; 03 medical and health sciences; 0302 clinical medicine; Predictive Value of Tests; hyperpolarized helium-3 magnetic resonance imaging; 616; 80 and over; Humans; Tomography; Lung; Aged; Aged, 80 and over; Analysis of Variance; Middle Aged; X-Ray Computed; 3. Good health; Plethysmography; emphysema; Diffusion Magnetic Resonance Imaging; Pulmonary Emphysema; Spirometry; Medical Biophysics; Xenon Isotopes; Female; Pulmonary Ventilation; Tomography, X-Ray Computed

In subjects with chronic obstructive pulmonary disease (COPD), hyperpolarized xenon-129 ((129)Xe) magnetic resonance imaging (MRI) reveals significantly greater ventilation defects than helium-3 ((3)He) MRI. The physiological and/or morphological determinants of and the differences observed between (3)He (129)Xe MRI are not yet understood. Here we aimed to determine structural basis for in COPD using apparent diffusion coefficients (ADC) computed tomography (CT). Ten ex-smokers provided written, informed consent underwent MRI, CT, spirometry, plethysmography. volume was generated semiautomated segmentation, ADC maps were registered generate values lung regions interest ventilated by both gases (ADCHX) gas only (ADCHO). CT wall area percentage lowest 15th percentile point density histogram (HU15%) also evaluated. For accessed only, mean ADCHO (ADCHO = 0.503 ± 0.119 cm(2)/s, ADCHX 0.470 0.125 P < 0.0001). difference correlated HU15% (r -65, 0.04) 0.70, 0.02), but -0.34, 0.33). conclusion, this small study subjects, decreased compared these spatially increased emphysema, airway thickness.