Properties of Deiters’ neurons and inhibitory synaptic transmission in the mouse lateral vestibular nucleus

• DOI: 10.1152/jn.00016.2022
• Publication Date: 2022-06-22T12:00:57Z
• Authors: I. M. Stitt; T. P. Wellings; H. R. Drury; P. Jobling; R. J. Callister; A. M. Brichta; R. Lim
• Keywords: Neurons; 571; Vestibular Nucleus, Lateral; immunolabeling; Vestibular Nuclei; electrophysiology; Synaptic Transmission; Mice; 03 medical and health sciences; 0302 clinical medicine; Spinal Cord; Animals; Deiters' neurons; gamma-Aminobutyric Acid; lateral vestibular nucleus

Deiters’ neurons within the lateral vestibular nucleus project the length of the spinal cord and activate antigravity extensor muscles. Deiters’ neurons were characterized anatomically and physiologically in mice. Deiters’ neurons are tonically active, have homogeneous intrinsic membrane properties, including low input resistance, and receive significant GABAAergic synaptic inputs. Deiters’ neurons show little modulation in response to current injection. These features are consistent with Deiters’ neurons responding to perturbations to maintain posture and balance.