Cannabinoid agonists inhibit the activation of 5-HT3 receptors in rat nodose ganglion neurons

• DOI: 10.1152/jn.1995.73.2.907
• Publication Date: 2017-12-25T04:12:39Z
• Authors: P. Fan
• Keywords: Nodose Ganglion; Cannabinoid receptor antagonist; Anandamide

1. Effects of cannabinoid agonists on the serotonin (5-HT)3 receptor-mediated current were investigated in rat nodose ganglion neurons. Anandamide, Win 55212-2, and CP55940 inhibited 5-HT-induced a concentration dependent manner. IC50 values 190, 310, 94 nM for anandamide, CP55940, respectively, 1.6 microM nonpsychoactive enantiomer CP56667. This inhibition was slowly developing, noncompetitive, not membrane potential, affected by adenosine 3',5'-cyclic monophosphate (cAMP) analogues, guanosine-5'-O-(2-thiodiphosphate) (GDP-beta-S), opioid receptor antagonist naltrexone. These data suggest that 5-HT3 ion-channel is site acted upon nervous system, action receptors may be possible mechanism some behavioral effects cannabinoids, such as antiemesis analgesia.