Function of the Hyperpolarization-Activated Inward Rectification in Nonmyelinated Peripheral Rat and Human Axons

• DOI: 10.1152/jn.1997.77.1.421
• Publication Date: 2017-12-25T01:09:16Z
• Authors: Peter Grafe; Stefan Quasthoff; Julian Grosskreutz; Christian Alzheimer
• Keywords: Hyperpolarization

Grafe, Peter, Stefan Quasthoff, Julian Grosskreutz, and Christian Alzheimer. Function of the hyperpolarization-activated inward rectification in nonmyelinated peripheral rat human axons. J. Neurophysiol. 77: 421–426, 1997. The function time-dependent, was analyzed on compound potentials axons mammalian nervous system. Isolated vagus nerves fascicles biopsied sural nerve were tested a three-chambered, Vaseline-gap organ bath at 37°C. Inward assessed by recording effects long-lasting hyperpolarizing currents electrical excitability with use method threshold electrotonus (program QTRAC, copyright Institute Neurology, London, UK) measuring activity-dependent changes conduction velocity membrane potential. Prominent cesium-sensitive revealed to 200-ms current pulses. A slowing action potential observed during gradual increase stimulation frequency from 0.1 3 Hz. Above 0.3 Hz, this enhanced application 1 mM cesium. Cesium did not alter waveforms frequencies <1 Cesium-induced correlated hyperpolarization. hyperpolarization cesium stronger higher small unstimulated nerves. These data show that cesium-sensitive, time-dependent fibers limits seen such than ∼0.3