Brown Fat: A Beta Way to Burn Calories, but Which Beta?

• DOI: 10.1152/physiol.2024.39.s1.1034
• Publication Date: 2024-05-21T14:57:50Z
• Authors: Taylor Ewell; Matthew Bomar; David Brown; Reagan Cyphers; Beatrice Kwarteng; David Thomson; Blair Johnson
• Keywords: BETA (programming language); Calorie

Brown fat is a thermogenic tissue that may have therapeutic value for the treatment of obesity and diabetes. That brown under sympathetic control indisputable, but considerable controversy exists as to which beta-adrenergic receptor subtypes, b 1 AR, 2 AR or 3 primary regulator. The purpose current study was determine if co-administration agonist, mirabegron, would increase energy expenditure activation more than non-selective bAR stimulation (isoproterenol) alone. 14 healthy, active young adults (8 males, 6 females) participated in randomized crossover study. Energy temperature-controlled room (22.1 deg C, 48.5% relative humidity) determined at rest after ingestion placebo mirabegron (100mg), prior intravenous administration isoproterenol (30 minutes 6, 12, 24 ng/kg free mass/min). activity estimated using supraclavicular skin temperature assessed via infrared thermography. Baseline not different ( P=0.42) (1487±106 kcal/day; (mean±SE)) (1424±104 kcal/day). Non-selective increased above baseline (11.6±5.5, 15.2±6.3 20.1±6.0%; P<0.05); additional did augment this response (18.0±3.8, 23.2±4.2 27.8±4.5%; P>0.05). P=0.95) (35.004±0.967 ◦ C) (34.992±0.967 C). Only greatest dose (0.236±0.082 C); (0.100±0.082 C; P=0.09). Co-administration agonist These preliminary data imply might be regulator humans. Offce Naval Research N00014-21-1-2276. This full abstract presented American Physiology Summit 2024 meeting only available HTML format. There are no versions content abstract. involved peer review process.