The uterine secretory cycle: recurring physiology of endometrial outputs that setup the uterine luminal microenvironment

• DOI: 10.1152/physiolgenomics.00035.2023
• Publication Date: 2023-09-11T08:31:51Z
• Authors: Kasey M. Schalich; Prasanthi P. Koganti; Juan M. Castillo; Olivia M. Reiff; Soon Hon Cheong; Vimal Selvaraj
• Keywords: Reproductive physiology

Conserved in female reproduction across all mammalian species is the estrous cycle and its regulation by hypothalamic-pituitary-gonadal (HPG) axis, a collective of intersected hormonal events that are crucial for ensuring uterine fertility. Nonetheless, knowledge direct mediators synchronously shape microenvironment successive yet distinct events, such as transit sperm support progressive stages preimplantation embryo development, remain principally deficient. Toward understanding timed endometrial outputs permit luminal directed cycle, we used Bovidae model system to uniquely surface sample study temporal shifts vivo transcripts encode proteins destined be secreted. The results revealed full quantitative profile components at phases (estrus, metestrus, diestrus, proestrus). In interpreting this comprehensive log stage-specific secretions, define "uterine secretory cycle" extract predictive recurring physiological actions regulated within lumen anticipation embryonic stages. This repetitive microenvironmental preparedness sequentially provide operative was stable intrinsic framework, with only limited responses or embryos if encountered cyclic time period. uncovering unraveling realistic biological processes, present novel foundational terminal effectors controlled HPG axis sequence vital functions lumen.NEW & NOTEWORTHY unravels changes uterus supports (sperm development stages) during reproductive Ruminantia. These data new systems physiology setting up vitro biomimicry artificial environments assisted technologies range species.