Influence of diet and genetics on hypertension and renal disease in Dahl salt-sensitive rats

• DOI: 10.1152/physiolgenomics.00151.2003
• Publication Date: 2004-01-31T01:05:02Z
• Authors: David L. Mattson; Mary Pat Kunert; Mary L. Kaldunski; Andrew S. Greene; Richard J. Roman; Howard J. Jacob; Allen W. Cowley
• Keywords: Low-protein diet

Experiments examined the influence of diet and genetics on hypertension renal disease in inbred Dahl salt-sensitive (SS/Mcw) rats consomic which chromosomes 16 (SS.BN16) or 18 (SS.BN18) normotensive Brown Norway rat were inserted into genetic background SS/Mcw. SS/Mcw breeders offspring randomly placed a purified AIN-76A grain-based diet, male screened for cardiovascular phenotypes following 3 wk 4.0% NaCl diet. High-salt arterial blood pressure (162 ± 5 mmHg, n = 10), urinary protein excretion (147 mg/day, 14), albumin (72 9 14) significantly elevated maintained compared with fed Rats also exhibited more glomerular tubular damage than grain Moreover, feeding to parents led significant increase offspring, regardless Similar dietary effects observed SS.BN16 SS.BN18 rats. In substitution decrease pressure, excretion, Chromosomal did not, however, affect when These data demonstrate composition salt-induced rat.