Hormone Replacement Therapy and Risk for Neurodegenerative Diseases

• DOI: 10.1155/2012/258454
• Publication Date: 2012-04-04T21:00:57Z
• Authors: Richelin V. Dye; Karen J. Miller; Elyse J. Singer; Andrew J. Levine
• Keywords: Neurocognitive

Over the past two decades, there has been a significant amount of research investigating risks and benefits hormone replacement therapy (HRT) with regards to neurodegenerative disease. Here, we review basic science studies, randomized clinical trials, epidemiological discuss putative neuroprotective effects HRT in context Alzheimer's disease, Parkinson's frontotemporal dementia, HIV-associated neurocognitive disorder. Findings date suggest reduced risk disease improved cognitive functioning postmenopausal women who use 17β-estradiol. With is consistent evidence from studies for effect 17β-estradiol; however, results are inconclusive at this time, paucity examining association between Parkinson's-related impairment. Even less understood on dementia Limits existing discussed, along proposed future directions investigation diseases.