Toxicological Features ofCatha edulis(Khat) on Livers and Kidneys of Male and Female Sprague-Dawley Rats: A Subchronic Study

• DOI: 10.1155/2012/829401
• Publication Date: 2012-11-27T16:03:09Z
• Authors: Abdulsamad Alsalahi; Mahmood Ameen Abd...; Mohammed Al-Mamary; Mohamed Ibrahim N...; Siddig Ibrahim Ab...; Aied M. Alabsi; Abdrabuh Shwter; Mohammed A. Alshawsh
• Keywords: Khat; Nephrotoxicity

Hepato- and nephrotoxicity of Khat consumption ( Catha edulis Forskal) have been evoked. Therefore, this study was conducted to evaluate such possible hepatorenal toxicity in female male Sprague-Dawley rats (SD rats) focusing primarily on liver kidney. In addition, were investigated separately. Accordingly, forty-eight SD-rats (100–120 g) distributed randomly into four groups males (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>12</mml:mn></mml:mrow></mml:math>). Normal controls (NCs) received distilled water, whereas test 500 mg/kg (low dose (LD)), 1000 (medium (MD)), or 2000 (high (HD)) crude extract orally for 4 weeks. Then, physical, biochemical, hematological, histological parameters analyzed. Results Khat-fed showed hepatic enlargement, abnormal findings serum aspartate aminotransferase (AST), alkaline phosphatase (ALP) albumin (A) creatinine (Cr) as compared controls. histopathological abnormalities confirmed renal toxicities that related heavy consumption. summary, could be associated with hypertrophy hepatotoxicity only SD-rats.