Protective Nature of Mangiferin on Oxidative Stress and Antioxidant Status in Tissues of Streptozotocin-Induced Diabetic Rats

• DOI: 10.1155/2013/750109
• Publication Date: 2013-09-12T21:05:49Z
• Authors: Periyar Selvam Se...; Palanisamy Arulse...; Subban Kamalraj; Sharida Fakurazi; Murugesan Kandasamy
• Keywords: Mangiferin

Oxidative stress plays an important role in the progression of diabetes complications. The aim present study was to investigate beneficial effect oral administration mangiferin streptozotocin (STZ)-induced diabetic rats by measuring oxidative indicators liver and kidney as well ameliorative properties. Administration significantly decreased blood glucose increased plasma insulin levels. activities antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) level reduced (GSH) were (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi>P</mml:mi><mml:mo>&lt;</mml:mo><mml:mn>0.05</mml:mn></mml:mrow></mml:math>) while increases levels lipidperoxidation (LPO) markers observed tissues control compared normal rats. Oral treatment with (40 mg/kg b.wt/day) for a period 30 days showed significant effects on all biochemical parameters studied. Diabetic treated restored almost architecture tissues, which confirmed histopathological examination. These results indicated that has potential addition its antidiabetic experimentally induced