Epidemiology and Virulence Determinants including Biofilm Profile ofCandidaInfections in an ICU in a Tertiary Hospital in India

• DOI: 10.1155/2014/303491
• Publication Date: 2014-01-12T21:01:40Z
• Authors: Ravinder Kaur; Ritu Goyal; Megh S. Dhakad; Preena Bhalla; Rakesh Kumar
• Keywords: Candida parapsilosis; Broth microdilution; Candida glabrata; Candida krusei; Candida dubliniensis

The purpose of this prospective study was to isolate, speciate, and determine antifungal susceptibility virulence patterns Candida species recovered from the intensive care units (ICUs) in an Indian hospital. Study included 125 medical/postoperative patients admitted ICU. Identification speciation yeast isolates were done by biochemical methods. Antifungal broth microdilution method. Virulence testing phospholipase, proteinase, adherence assay. A total 103 isolated; C. tropicalis predominant (40.7%), followed albicans (38.83 %), glabrata (11.65%), parapsilosis (3.88%), 1.94% each krusei , kefyr sphaerica . 60 (58.25%) showed resistance fluconazole, while 7 (6.7%) amphotericin B. Phospholipase proteinase activities seen 73.8% 55.3% with different showing a wide range activities, 68.9% {4+} activity. present revealed that nonalbicans (NAC spp.) caused most cases Candidemia ICU patients. isolation large number highlights ability pathogen cause bloodstream infections. presence azole is matter concern.