Immunoregulatory Effects of Bone Marrow-Derived Mesenchymal Stem Cells in the Nasal Polyp Microenvironment

• DOI: 10.1155/2014/583409
• Publication Date: 2014-02-13T16:03:46Z
• Authors: Rogério Pezato; Danilo Cândido de...; Thiago Freire Bez...; Fernando de Sá Silva; Claudina Perez-Novo; Luís Carlos Gregório; Richard Louis Voe...; Niels Olsen Câmara; Claus Bachert
• Keywords: CD4-Positive T-Lymphocytes; MATRIX METALLOPROTEINASES; PARANASAL SINUS DISEASE; CHRONIC RHINOSINUSITIS; Bone Marrow Cells; CD8-Positive T-Lymphocytes; Lymphocyte Activation; DENDRITIC CELLS; 03 medical and health sciences; Nasal Polyps; INFLAMMATION; TISSUE INHIBITOR; Medicine and Health Sciences; 3-DIOXYGENASE EXPRESSION; Pathology; RB1-214; Humans; INDOLEAMINE 2; Cells, Cultured; Inflammation; 0303 health sciences; GROWTH-FACTOR-BETA; Forkhead Transcription Factors; Mesenchymal Stem Cells; Coculture Techniques; 3. Good health; Phenotype; Gene Expression Regulation; STROMAL CELLS; Cytokines; RESPONSES; Research Article

Nasal polyposis is a severe, chronic inflammatory condition of the paranasal sinuses and frequently associated with asthma aspirin sensitivity. Mesenchymal stem cells exhibit potent immunosuppressive effect in several conditions, their role nasal remains little explored. Hence, we investigated whether bone marrow-derived mesenchymal could modulate cell phenotype polyp milieu. After coculture cells, frequency these was found to decrease. Furthermore, promoted strong inhibition CD4+ CD8+ T proliferation, increased CD4+CD25+Foxp3 changed global cytokine profile from an anti-inflammatory response. We believe that may be very useful adjunct for investigation process polyposis, contributing better understanding course this condition.