CYP7A1Gene Polymorphism Located in the 5′ Upstream Region Modifies the Risk of Coronary Artery Disease

• DOI: 10.1155/2015/185969
• Publication Date: 2015-04-08T15:07:17Z
• Authors: Tomasz Iwanicki; Anna Balcerzyk; Pawel Niemiec; Tomasz Nowak; Anna Ochalska-Tyka; Jolanta Krauze; Sylwia Kosiorz-Go...; Wladyslaw Grzeszczak; Iwona Zak
• Keywords: Adult; Male; 0301 basic medicine; Coronary Artery Disease; Middle Aged; Lipids; Polymorphism, Single Nucleotide; 03 medical and health sciences; Phenotype; Case-Control Studies; Humans; Female; 5' Untranslated Regions; Cholesterol 7-alpha-Hydroxylase; Alleles; Research Article

7-Alpha cholesterol hydroxylase (CYP7A1), the first enzyme of classic conversion pathway leading from to bile acids synthesis, is encoded by CYP7A1 gene. Its single nucleotide polymorphisms (SNPs) influence serum lipid levels and may be related impaired profile coronary artery disease (CAD). The aim present study was analyze possible association between rs7833904 polymorphism premature CAD. Serum SNP were determined in 419 subjects: 200 patients with CAD 219 age sex matched controls. A allele carrier state associated (OR = 1.76, 95% CI; 1.14-2.71, P 0.014). effect even stronger male subgroups 2.16, 1.28-3.65, 0.003). There no females. Risk factors clinical phenotype atherosclerosis not genotype variants SNP. Lipid profiles also did differ significantly individual genotypes. modify risk This especially strong subjects. studied does levels, study.