Is Infusion of Subhypnotic Propofol as Effective as Dexamethasone in Prevention of Postoperative Nausea and Vomiting Related to Laparoscopic Cholecystectomy? A Randomized Controlled Trial

• DOI: 10.1155/2015/349806
• Publication Date: 2015-01-28T21:02:02Z
• Authors: Mine Celik; Aysenur Dostbil; Mehmet Aksoy; Ilker Ince; Ali Ahiskalioglu; Mehmet Comez; Ali Fuat Erdem
• Keywords: Male; Incidence; Middle Aged; Dexamethasone; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Cholecystectomy, Laparoscopic; Double-Blind Method; Postoperative Nausea and Vomiting; Clinical Study; Antiemetics; Humans; Hypnotics and Sedatives; Female; Propofol; Infusion Pumps

Background . Postoperative nausea and vomiting (PONV) is one of common complications in patients undergoing laparoscopic cholecystectomy (LC). Aim this study was to compare the efficacy subhypnotic (1 mg/kg/h) infusion propofol with dexamethasone on PONV LC. Methods A total 120 were included randomized, double-blind, placebo-controlled study. Patients randomly assigned 3 groups; group (group D) administrated 8 mg before induction anesthesia, P) infused during operation control C) applied 10% intralipid. The incidence needs for rescue analgesic antiemetic recorded first 24 h postoperatively. Results In 0–24 h, significantly lower D P compared C (37.5%, 40%, 72.5%, resp.). There no significant difference use antiemetics between P. Conclusion We concluded that 1 mg/kg/h as effective prevention hours after anesthesia