Neutrophilic Bronchial Inflammation Correlates with Clinical and Functional Findings in Patients with Noncystic Fibrosis Bronchiectasis

• DOI: 10.1155/2015/642503
• Publication Date: 2015-12-27T21:03:11Z
• Authors: Federico L. Dente; Marta Bilotta; Maria Laura Bartoli; Elena Bacci; Silvana Cianchetti; Manuela Latorre; Laura Malagrinò; Dario Nieri; Maria Adelaide Roggi; Barbara Vagaggini; Pierluigi Paggiaro
• Keywords: Adult; Inflammation; Male; Neutrophils; Sputum; Bronchi; Middle Aged; Severity of Illness Index; Bronchiectasis; 3. Good health; Oxidative Stress; 03 medical and health sciences; Immunology; Cell Biology; Cross-Sectional Studies; 0302 clinical medicine; Breath Tests; Forced Expiratory Volume; Pathology; RB1-214; Humans; Female; Research Article; Aged

Background. Neutrophilic bronchial inflammation is a main feature of bronchiectasis, but not much known about its relationship with other disease features. Aim. To compare airway inflammatory markers clinical and functional findings in subjects stable noncystic fibrosis bronchiectasis (NCFB). Methods. 152 NFCB patients (62.6 years; females: 57.2%) underwent cross-sectional evaluation, including microbiologic cell profile sputum, exhaled breath condensate malondialdehyde (EBC-MDA). severity was assessed using BSI FACED criteria. Results. Sputum neutrophil percentages inversely correlated FEV1 (P < 0.0001; rho = -0.428), weakly Leicester Cough Questionnaire score 0.068; -0.58), directly duration the 0.004; 0.3) 0.005; 0.37), FACED. neutrophilia higher colonized subjects, P. aeruginosa showing greater sputum lower FEV1. Patients ≥3 exacerbations last year showed significantly EBC-MDA than remaining patients. Conclusions. neutrophilic biomarkers oxidative stress EBC can be considered good NCFB patients, as confirmed by pulmonary function, duration, bacterial colonization, score, exacerbation rate.